1 High - yield resveratrol production 1 in Engineered Escherichia coli
نویسندگان
چکیده
High-yield resveratrol production 1 in Engineered Escherichia coli 2 3 Chin Giaw Lim a , Zachary L. Fowler a , Thomas Hueller b , 4 Steffen Schaffer b and Mattheos A.G. Koffas a† 5 6 a Department of Chemical and Biological Engineering 7 University at Buffalo, the State University of New York 8 Buffalo, NY 14260 9 10 b Evonik Degussa GmbH 11 Creavis Technologies & Innovation 12 Paul-Baumann-Strasse 1 13 D-45772 Marl, Germany 14 15 Submitted for publication to Applied and Environmental Microbiology 16 17 † Corresponding author 18
منابع مشابه
High-yield resveratrol production in engineered Escherichia coli.
Plant polyphenols have been the subject of several recent scientific investigations since many of the molecules in this class have been found to be highly active in the human body, with a plethora of health-promoting activities against a variety of diseases, including heart disease, diabetes, and cancer, and with even the potential to slow aging. Further development of these potent natural ther...
متن کاملDe novo biosynthesis of pterostilbene in an Escherichia coli strain using a new resveratrol O-methyltransferase from Arabidopsis
BACKGROUND Pterostilbene, a structural analog of resveratrol, has higher oral bioavailability and bioactivity than that of the parent compound; but is far less abundant in natural sources. Thus, to efficiently obtain this bioactive resveratrol analog, it is necessary to develop new bioproduction systems. RESULTS We identified a resveratrol O-methyltransferase (ROMT) function from a multifunct...
متن کاملEngineering of a microbial coculture of Escherichia coli strains for the biosynthesis of resveratrol
BACKGROUND Resveratrol is a plant natural product with many health-protecting effects which makes it an attractive chemical both for academic studies and industrial purposes. However, the low quantities naturally produced by plants as well as the unsustainable procedures of extraction, purification and concentration have prompted many biotechnological approaches to produce this chemical in larg...
متن کاملProduction of chondroitin in metabolically engineered E. coli.
Chondroitin sulfates, widely used in the treatment of arthritis, are glycosaminoglycans extracted from food animal tissues. As part of our ongoing efforts to separate the food chain from the drug chain, we are examining the possibility of using metabolic engineering to produce chondroitin sulfate in Escherichia coli. Chondroitin is a valuable precursor in the synthesis of chondroitin sulfate. T...
متن کاملEfficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coli
BACKGROUND Due to its abundance and low-price, glycerol has become an attractive carbon source for the industrial production of value-added fuels and chemicals. This work reports the engineering of E. coli for the efficient conversion of glycerol into L-lactic acid (L-lactate). RESULTS Escherichia coli strains have previously been metabolically engineered for the microaerobic production of D-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011